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先端医療技術の開発・支援事業 株式会社デンドリックス

論文実績

Conjugation to octa-arginine via disulphide bonds confers solubility to denatured proteins in physiological solution and enables efficient cell-internalization.

著書:野口活夫

共著者

Kuwada E, Tadaki T, Kambara K, Egawa K and Noguchi K.

掲載誌

Biotechnol. Appl. Biocem. 2011, 58 : 439-448.
DOI: 10. 1002/bab.59

Insoluble fraction of tumor cell homogenate is a useful material for eliciting cytotoxic T lymphocytes: A unique method for protein solubilization.

著書:野口活夫

共著者

Kuwada E., Kambara K., Tadaki T. and Noguchi K.

掲載誌

Anticancer Res. 2011, 31 : 881-892.

A novel strategy of cancer gene therapy by transcriptional targeting of an allogeneic histocompatibility transgene.

著書:野口活夫

共著者

Kuwada E., Noguchi K., Seo N., Yamashiro H. and Egawa K.

掲載誌

Anticancer Res. 2009, 29 : 1015-1022.

Tumor cell-specific gene expression by 5’-flanking DNA of murine Q5 gene in an adenoviral vector system.

著書:野口活夫

共著者

Kuwada E., Noguchi K., Hasezawa K. and Egawa K.

掲載誌

Anticancer Res. 2008, 28 : 799-812.

Detection of anti-HLA-F antibodies in sera from cancer patients.

著書:野口活夫

共著者

Noguchi K., Isogai M., Kuwada E., Noguchi A., Goto S. and Egawa K.

掲載誌

Anticancer Res. 2004, 24 : 3387.

Tumor cell-specific transcription of a murine histocompatibility class Ib Q5 gene.

著書:野口活夫

共著者

Noguchi K., Kuwada E., Goto S. and Egawa K.

掲載誌

Anticancer Res. 2004, 24 : 3379.

Clinical benefit of non-toxic therapy in patients with Advanced Cancer (Opinion).

著書:野口活夫

共著者

Goto S., Shirotani S., Hatakeyama M., Tagami C., Arakawa H., Kuwada E., Noguchi K. and Egawa K.

掲載誌

Anticancer Res. 2002, 22 : 2461.

Tumor necrosis factor alpha (TNFalpha)-like factor produced by macrophages in rainbow trout, Oncorhynchus mykiss.

著書:野口活夫

共著者

Qin QW., Ototake M., Noguchi K., Soma G., Yokomizo Y., Nakanishi T.

掲載誌

Fish Shellfish Immunol. 2001, 11 : 245.

Lipid A誘導体ONO-4007の化学療法剤との併用による抗腫瘍効果の増強 (II)

著書:野口活夫

共著者

野口活夫,稲川裕之,南村昌志,西沢孝志,高木幸一,水野伝一,杣源一郎

掲載誌

Biotherapy 1998, 12 : 809.

高濃度TNFの投与を可能とするisolation hepatic perfusion法による肝転移に対する新規制癌療法確立のための基礎的検討

著書:野口活夫

共著者

高木幸一, 稲川裕之, 福島ゆかり, 野口活夫, 高野正博, 杣源一郎

掲載誌

Biotherapy 1998, 12 : 758.

Immunoglobulinによる腸管マクロファージからのTNF産生の増強

著書:野口活夫

共著者

南村昌志,野口活夫,稲川裕之,本田晃子,田代和弘,高木幸一,高野正博,杣源一郎

掲載誌

Biotherapy 1998, 12 : 755.

Anti-tumor effect of lipopolysaccharide by intradermal administration as a novel drug delivery system.

著書:野口活夫

共著者

Inagawa H., Nishizawa T., Noguchi K., Minamimura M., Takagi K., Goto S., Soma G.-I., and Mizuno D.

掲載誌

Anticancer Res. 1997, 17 : 2153.

Antitumor mechanism of intradermal administration of lipopolysaccharide.

著書:野口活夫

共著者

Inagawa H., Nishizawa T., Noguchi K., Goto S., Soma G.-I., and Mizuno D.

掲載誌

Anticancer Res. 1997, 17 : 1961.

Lipid A誘導体ONO-4007の化学療法剤との併用による抗腫瘍効果の増強

著書:野口活夫

共著者

野口活夫,稲川裕之,南村昌志,西沢孝志,高木幸一,水野伝一,杣源一郎

掲載誌

Biotherapy 1997, 11 : 461.

ヒト腸管マクロファージ画分の分離と精製の試み

著書:野口活夫

共著者

南村昌志,野口活夫,稲川裕之,本田晃子,西沢孝志,福島ゆかり,加納順子,高木幸一,高野正博,杣源一郎

掲載誌

Biotherapy 1997, 11 : 428.

Bidirectional feedback regulation on 17 kDa tumor necrosis factor production by 26 kDa membrane-bound tumor necrosis factor precursor.

著書:野口活夫

共著者

Soma G.-I., Nishizawa T., Inagawa H., Tanabe Y., Noguchi K., Goto S., Takagi K. and Mizuno D.

掲載誌

J. Inflammation 1996, 47 : 52.

Antitumor mechanisms of intradermal administration of lipopolysaccharide which induced high antitumor effect on experimental tumors due to its slow release of effecter molecules.

著書:野口活夫

共著者

Inagawa H., Nishizawa T., Noguchi K., Kanou J., Minamimura M., Goto S., Soma G.-I. and Mizuno D.

掲載誌

Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 1996, 23 : 196.

Induction of differentiation in embryonic stem cells by 26-kD membrane-bound tumor necrosis factor ( TNF ) and 17-kD free TNF.

著書:野口活夫

共著者

Kohchi C., Tanabe Y., Noguchi K., Mizuno D. and Soma G.-I.

掲載誌

in vivo 1996, 10 : 19.

Pantoea Agglomerans 由来リポ多糖の低分子分画及び高分子分画リポ多糖の生物活性の検討

著書:野口活夫

共著者

西沢孝志,稲川裕之,野口活夫,池田耕一,水野伝一,杣源一郎

掲載誌

Biotherapy 1996, 10 : 519.

大腸癌細胞のTNF 産生能とヌードマウス盲腸への同所移植による生着性と転移能との関連

著書:野口活夫

共著者

稲川裕之,野口活夫,福島ゆかり,南村昌志,西沢孝志,高木幸一,高野正博,杣源一郎

掲載誌

Biotherapy 1996, 10 : 397.

麻酔犬モデルにおける組み換え型ヒト腫瘍壊死因子(TNF)-α,TNF-SAM2 とリポソーム結合型TNF-SAM2の血行動態評価

著書:野口活夫

共著者

加納順子,Klostergaard J.,Lodato R. F.,Barry F.,Akimaru K.,野口活夫,南村昌志,杣源一郎

掲載誌

Biotherapy 1996, 10 : 389.

Free C8-TNF-SAM2と C8-TNF-SAM2の抗腫瘍効果

著書:野口活夫

共著者

野口活夫,Klostergaard J.,Auzenne E.,Akimaru K.,Leroux M.E.,Akimaru Y.,加納順子,南村昌志,杣源一郎

掲載誌

Biotherapy 1996, 10 : 307.

Augmentation of specific tumor killing activity by tumor-infiltrating lymphocyte(TIL) in the presence of TNF-SAM2.

著書:野口活夫

共著者

Goto S., Suma Y., Noguchi K., Kera J., Sakai S., Soma G.-I., Takeuchi S.

掲載誌

Cancer Biotherapy 1995, 10 : 37.

Predominance of rTNF-SAM2 with higher therapeutic index than conventional TNA-α is ascribed to the style of oligomer.

著書:野口活夫

共著者

Noguchi K., Bos E., Kanou J., Minamimura M., Mizuno D. and Soma G.-I.

掲載誌

Eur. Cytokine Netw. 1994, 5 : 183.

Acceleration of differentiation in embryonic stem cells by membrane-bound TNF as well as mature TNF.

著書:野口活夫

共著者

Kohchi C., Tanabe Y., Noguchi K., Mizuno D. and Soma G-I.

掲載誌

Eur. Cytokine Netw. 1994, 5 : 90.

Constitutive expression of TNF-α and -β genes in mouse embryo : Roles of cytokines as regulator and effecter on development.

著書:野口活夫

共著者

Kohchi C., Noguchi K., Mizuno D. and Soma G-I.

掲載誌

Int. J. Biochem. 1994, 26 : 111.

rTNF-SAM2と DDS ( drug delivery system ) の応用による治療係数の向上  – 第3世代TNF作製の試み –

著書:野口活夫

共著者

野口活夫,Klostergaard J.,Lodato R. F.,Akimaru K.,Hung M-C.,加納順子,南村昌志,水野伝一,杣源一郎

掲載誌

Biotherapy 1994, 8 : 406.

Advantages of rTNF-SAM2 as an anti-tumor drug judged from biological activities.

著書:野口活夫

共著者

Noguchi K., Kanou J., Tanabe N., Tanabe Y., Mizuno D. and Soma G.-I.

掲載誌

Eur. Cytokine Netw. 1992, 3 : 243.

Expression of TNF-α, β and complements transcripts in embryonal carcinoma and trophoblast cell lines.

著書:野口活夫

共著者

Kohchi C., Noguchi K., Mizuno D. and Soma G.-I.

掲載誌

Eur. Cytokine Netw. 1992, 3 : 205.

Possible significance of TNF precursor on the cell surface of primed macrophages.

著書:野口活夫

共著者

Tanabe Y., Noguchi K., Mizuno D. and Soma G.-I.

掲載誌

Eur. Cytokine Netw. 1992, 3 : 159.

Purification of recombinant human tumor necrosis factor precursor from Escherichia coli.

著書:野口活夫

共著者

Tanabe Y., Noguchi K., Mizuno D. and Soma G.-I.

掲載誌

Biochem. Biophys. Res. Commun. 1991, 179 : 683.

Antitumor activity of novel chimera tumor necrosis factor (TNF-STH) constructed by connecting rTNF-S with thymosin β4 against murine syngeneic tumors.

著書:野口活夫

共著者

Noguchi K., Inagawa H., Tsuji Y., Morikawa A., Mizuno D. and Soma G.-I.

掲載誌

J. Immunotherapy 1991, 10 : 105.

Production in Escherichia coli of human thymosin β4 as chimeric protein with human tumor necrosis factor.

著書:野口活夫

共著者

Tsuji Y., Tanabe N., Noguchi K., Gatanaga T., Mizuno D. and Soma G.-I.

掲載誌

Biochem. Intern. 1989, 18 : 501.

Antitumor effect of systemic administration of novel recombinant tumor necrosis factor ( rTNF-S ) with less toxicity than conventional rTNF-α in vivo.

著書:野口活夫

共著者

Gatanaga T., Noguchi K., Tanabe Y., Inagawa H., Soma G.-I. and Mizuno D.

掲載誌

J. Biol. Response Modif. 1988, 8 : 278.

Biological activity of novel recombinant tumor necrosis factor having N-terminal amino acid sequence derived from cytotoxic factors produced by THP-1 cells.

著書:野口活夫

共著者

Soma G.-I., Tsuji Y., Tanabe Y., Noguchi K., Tanabe N., Gatanaga T., Inagawa H., Kawakami M. and Mizuno D.

掲載誌

J. Biol. Response Modif. 1988, 7 : 587.

Improvement of cytotoxicity of tumor necrosis factor (TNF) by increase in basicity of its N-terminal region.

著書:野口活夫

共著者

Soma G.-I., Kitahara N., Tsuji Y., Kato M., Ohshima H., Gatanaga T., Inagawa H., Noguchi K., Tanabe Y. and Mizuno D.

掲載誌

Biochem. Biophys. Res. Commun. 1987, 148 : 629.

Structure and function of 10Sa RNA: trans-translation system.

著書:只木敏雅

共著者

Muto A, Sato M, Tadaki T, Fukushima M, Ushida C, Himeno H

掲載誌

Biochimie. 1996;78 (11-12):985-91.

Interaction of 10Sa RNA with ribosomes in Escherichia coli.

著書:只木敏雅

共著者

Tadaki T, Fukushima M, Ushida C, Himeno H, Muto A.

掲載誌

FEBS Lett. 1996 Dec 16;399 (3):223-6.

Escherichia coli tmRNA (10Sa RNA) in trans-translation.

著書:只木敏雅

共著者

Himeno H, Nameki N, Tadaki T, Sato M, Hanawa K, Fukushima M, Ishii M, Ushida C, Muto A.

掲載誌

Nucleic Acids Symp Ser. 1997;(37):185-6.

Amino acid acceptor identity switch of Escherichia coli tmRNA from alanine to histidine in vitro

著書:只木敏雅

共著者

Nameki N, Tadaki T, Muto A, Himeno H.

掲載誌

J Mol Biol. 1999 May 28;289 (1):1-7.

Three of four pseudoknots in tmRNA are interchangeable and are substitutable with single-stranded RNAs.

著書:只木敏雅

共著者

Nameki N, Tadaki T, Himeno H, Muto A.

掲載誌

FEBS Lett. 2000 Mar 31;470 (3):345-9.

Determinants on tmRNA for initiating efficient and precise trans-translation: some mutations upstream of the tag-encoding sequence of Escherichia coli tmRNA shift the initiation point of trans-translation in vitro.

著書:只木敏雅

共著者

Lee S, Ishii M, Tadaki T, Muto A, Himeno H.

掲載誌

RNA. 2001 Jul;7 (7):999-1012.

Detection of tmRNA-mediated trans-translation products in Bacillus subtilis.

著書:只木敏雅

共著者

Fujihara A, Tomatsu H, Inagaki S, Tadaki T, Ushida C, Himeno H, Muto A.

掲載誌

Genes Cells. 2002 Mar;7 (3):343-50.

Trans-translation mediated by Bacillus subtilis tmRNA.

著書:只木敏雅

共著者

Ito K, Tadaki T, Lee S, Takada K, Muto A, Himeno H.

掲載誌

FEBS Lett. 2002 Apr 10;516 (1-3):245-52.

Efficient priming and expansion of antigen-specific CD8+ T cells by a novel cell-based artificial APC.

著書:只木敏雅

共著者

Sasawatari S, Tadaki T, Isogai M, Takahara M, Nieda M, Kakimi K.

掲載誌

Immunol Cell Biol. 2006 Dec;84 (6):512-21. Epub 2006 Jul 20.

The role of UvrD in RecET-mediated illegitimate recombination in Escherichia coli.

著書:只木敏雅

共著者

Shiraishi K, Imai Y, Yoshizaki S, Tadaki T, Ogata Y, Ikeda H.

掲載誌

Genes Genet Syst. 2006 Aug;81 (4):291-7.

Anti-infective and anti-tumor agents based on the depletion of immune suppressive effects.

著書:只木敏雅

共著者

Seo N, Yamashiro H, Tadaki T.

掲載誌

Curr Med Chem. 2008;15 (10):991-6.

Stimulation of human butyrophilin 3 molecules results in negative regulation of cellular immunity.

著書:只木敏雅

共著者

Yamashiro H, Yoshizaki S, Tadaki T, Egawa K, Seo N.

掲載誌

J Leukoc Biol. 2010 Oct;88 (4):757-67. doi: 10.1189/jlb.0309156. Epub 2010 Jul 7.

Insoluble fraction of tumor cell homogenate is a useful material for eliciting cytotoxic T lymphocytes: a unique method for protein solubilization.

著書:只木敏雅

共著者

Kuwada E, Kambara K, Tadaki T, Noguchi K.

掲載誌

Anticancer Res. 2011 Mar;31 (3):881-91.

Conjugation to octa-arginine via disulfide bonds confers solubility to denatured proteins in physiological solution and enables efficient cell internalization.

著書:只木敏雅

共著者

Kuwada E, Tadaki T, Kambara K, Egawa K, Noguchi K.

掲載誌

Biotechnol Appl Biochem. 2011 Nov-Dec;58 (6):439-48. doi: 10.1002/bab.59. Epub 2011 Nov 3.